Intra-articular CNTX-4975 for osteoarthritis knee pain: subgroup and post hoc analyses of a randomized phase 2 study
نویسندگان
چکیده
منابع مشابه
Intra-articular hyaluronans: the treatment of knee pain in osteoarthritis
The etiology of pain in osteoarthritis is multifactoral, and includes mechanical and inflammatory processes. Intra-articular injections of hyaluronans (HAs) are indicated when non-pharmacological and simple analgesics have failed to relieve symptoms. The HAs appear to reduce pain by restoring both mechanical and biomechanical homeostasis in the joint. There are five FDA-approved injectable prep...
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In a session dedicated to new treatment options for osteoarthritis (OA), two talks focused on promising results from phase 2 clinical trials. Yusuf Yazici (NYU School of Medicine, USA) presented week 26 interim analysis from a randomized, double-blind, placebo-controlled, phase 2 study using the novel WNT pathway inhibitor (SM04690) to treat knee OA (NCT02536833). Knee OA is characterized by de...
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1 Assoc Prof, Department of Anaesthesiology, MKCG Medical College, Berhampur, Odisha 2 Prof, Department of Anaesthesiology, MKCG Medical College, Berhampur, Odisha Corresponding Author Dr Narayan Acharya Assoc Prof Department of Anaesthesiology, MKCG Medical College, Berhampur, Odisha Email: [email protected], Mobile no-7008115431 Abstract Background: No single ideal intra-articular drug ...
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BACKGROUND Osteoarthritis (OA) is a degenerative disease that can lead to painful and dysfunctional joints. Prolotherapy involves using injections to produce functional restoration of the soft tissues of the joint. Intra-articular injections are controversial because of the introduction of needles into the articular capsule. OBJECTIVES To compare the effect of periarticular versus intra-artic...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2019
ISSN: 1063-4584
DOI: 10.1016/j.joca.2019.02.560